Topical Pressure Lowering Drug: Racial Respond Variation and Pharmacogenetics
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Editorial Commentary Pharmacogenetics of Antihypertensive Response
The widespread variation in individual response to antihypertensive treatment motivates a search for genetic factors associated with this variation. Pharmacogenetics evaluates the role of genetic variation in drug response, and pharmacogenomics applies pharmacogenetics to variants throughout the entire genome. The report by Turner et al in this issue of Hypertension is a pharmacogenomic study t...
متن کاملRole of pharmacogenomics in the drug development.
Individuals respond differently to drugs and sometimes the effects are unpredictable. Differences in DNA that alter the expression or function of proteins targeted by drugs can contribute significantly to the variation in the individuals responses. The use of pharmacogenomics is to identify genetic polymorphisms that predispose patients to adverse drug effects that, although they may occur in o...
متن کاملAntihypertensive pharmacogenetics: getting the right drug into the right patient.
Pharmacogenetic investigation seeks to identify genetic factors that contribute to interpatient and interdrug variation in responses to antihypertensive drug therapy. Classical studies have characterized single gene polymorphisms of drug metabolizing enzymes that are responsible for large interindividual differences in pharmacokinetic responses to several antihypertensive drugs. Progress is bei...
متن کاملHow personalized medicine became genetic, and racial: Werner Kalow and the formations of pharmacogenetics.
Physicians have long puzzled over a well-known phenomenon: different patients respond differently to the same treatment. Although many explanations exist, pharmacogenetics has now captured the medical imagination. While this might seem part of the broader interest in all things genetic, the early history of pharmacogenetics reveals the specific factors that contributed to the emergence of genet...
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The objective of the study was to evaluate the antiglaucoma effect of calcium channel blockers diltiazem and verapamil. Albino rabbits were used and chronic glaucoma was induced in them using freshly prepared 150 units of alphachymotrypsin. 0.1 mL of drug solution was administered topically into the left eye whereas the right served as control. The pressure recording was carried out at 15, 30, ...
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تاریخ انتشار 2017